I found different speeds and different roads help diagnose these problems. Freshly paved highways can be really helpful (the change in sound and the silence). The left lane and right lane are tilted to the left and right for drainage purposes so that might help (as do up and down hills, turns left and right, acceleration, gliding, gliding in neutral, braking, etc. Do these testing on roads with no traffic for safety.
You might put someone in the front seat then the back seat to see if they can identify where the sound is coming from.
Could be something else entirely, like a defective or worn tire, tire balance, wheel issue, alignment. Inexpensive tires can go in less than 20k miles. If the tires are say 10 years old the rubber gets pretty hard. Or maybe some brakes / suspension issue, etc.
I will say the rear-driver's side caliper pistons on these cars are not the greatest. On our 2013 LaCrosse 2.4 (car only has 50k miles and rear calipers were replaced TWICE). First replacement was at the dealer. We live in a salty area and the car gets a lot of city miles so those are factors.